Grapefruit Oil is an antioxidant and antiseptic. The smell of grapefruit is uplifting, soothing and clarifying. Its known to relieve stress and bring on feelings of peace and relaxation. Grapefruit oil may even beneficial for healing adrenal fatigue symptoms like low motivation, aches and sluggishness. Some people like to use grapefruit as a mild, natural antidepressant since it can increase alertness while also calming nerves.